• Oxaliplatin in Translational Oncology: Mechanisms, Microe...

  2025-09-29

  Explore the multifaceted role of Oxaliplatin, a platinum-based chemotherapeutic agent, in cancer chemotherapy. This article provides a unique translational perspective, bridging molecular mechanisms—such as DNA adduct formation and apoptosis induction—with innovations in patient-derived assembloid models to advance metastatic colorectal cancer therapy.

• Annexin V-FITC/PI Apoptosis Assay Kit: Transforming Chemo...

  2025-09-28

  Explore how the Annexin V-FITC/PI Apoptosis Assay Kit enables precise early apoptosis detection and cell death pathway analysis, with a unique focus on dissecting mechanisms of chemoresistance in colorectal cancer. Learn how this assay advances research beyond traditional applications.

• One-step TUNEL Cy3 Kit: Precision Apoptosis Detection in ...

  2025-09-27

  Explore how the One-step TUNEL Cy3 Apoptosis Detection Kit enables precise, fluorescent detection of apoptosis in both tissue sections and cultured cells. This in-depth article reveals advanced applications in translational cancer research, distinguishing its value for apoptosis and programmed cell death pathway studies.

• DMXAA (Vadimezan): Precision Disruption of Tumor Vasculat...

  2025-09-26

  Explore the advanced mechanisms of DMXAA (Vadimezan, AS-1404) as a vascular disrupting agent for cancer research. This article uniquely integrates latest insights on DT-diaphorase inhibition, VEGFR2 blockade, and emerging STING-JAK1 paradigms, delivering unmatched depth for cancer biology researchers.

• ARCA EGFP mRNA (5-moUTP): Advanced Strategies for Immune-...

  2025-09-25

  Explore how ARCA EGFP mRNA (5-moUTP) revolutionizes mRNA transfection in mammalian cells through innovative immune evasion, stability enhancement, and direct fluorescence detection. This article uniquely investigates the intersection of molecular design and storage science for next-generation research applications.

• Nitrocefin: Unraveling β-Lactamase Evolution and Resistan...

  2025-09-24

  Explore how Nitrocefin, a leading chromogenic cephalosporin substrate, enables advanced β-lactamase detection and mechanistic studies of antibiotic resistance evolution. This in-depth analysis unveils unique insights into enzyme specificity, resistance transfer, and next-generation assay strategies.

• Bortezomib (PS-341) as a Probe for Proteasome Inhibition ...

  2025-09-23

  Explore how Bortezomib (PS-341), a reversible proteasome inhibitor, advances research on proteasome-regulated cellular processes and reveals new intersections with pyrimidine salvage pathway regulation, providing unique insight for cancer therapy and apoptosis assays.

• Studies on both TCDD treated mice

  2025-03-03

  

  Studies on both TCDD treated mice and AhR null mice have also pointed to a role of AhR in hematopoiesis [65], [66]. Singh et al. showed that AhR is a negative regulator of HSC (hematopoietic stem cell) proliferation, while deletion of AhR leads to spleen enlargement in juvenile and adult mice [67].

• br Detection and possible treatments for prostate cancer

  2025-03-03

  

  Detection and possible treatments for prostate cancer PC can be diagnosed, by screening for prostate-specific antigen (PSA) and after diagnosis, treatments may include intense observation, radical prostatectomy, radiation, chemotherapy, hormone therapy or vaccination depending on the type and sta

• Previous studies suggest that TGF contributes to the pathoge

  2025-03-03

  

  Previous studies suggest that TGF-β contributes to the pathogenesis of diabetic renal injury [47]. TGF-β stimulates matrix production and prevents matrix degradation, which leads to increase collagen deposition and glomerulosclerosis [48]. In the current study ABT702 significantly reduced renal coll

• br Materials and methods br Results br Discussions

  2025-03-03

  

  Materials and methods Results Discussions Diabetes is mainly divided into Type 1 diabetes and Type 2 diabetes [16]. Type 2 diabetes, featured by insulin resistance, results from environmental factors and poor eating habits [2]. Type 2 diabetes accounts for more than 95% of the diabetic pati

• The next level of possible correlation

  2025-03-03

  

  The next level of possible correlation and comparison between the α7 and 5HT3 receptors is at the subunit arrangement and protein folding. Crystal structures of the nicotinic and serotoninergic Alisol A receptors [45], [46] reinforced the concept of similarities between these families of receptors.

• The following are the supplementary

  2025-03-03

  

  The following are the supplementary data related to this article. Funding Work in Dr. Rosell's laboratory is partially supported by a grant from La Caixa Foundation, and an Instituto de Salud Carlos III grant (RESPONSE, PIE16/00011). Work in Dr. Cao's laboratory is partially supported by the Maj

• Recently competitive inhibitors of arginase have been develo

  2025-03-01

  

  Recently, competitive inhibitors of arginase have been developed which have greater specificity for the enzyme. Initial development of these compounds involved determination of the crystal structure of arginase. Christianson and colleagues found that a binuclear manganese cluster was required for ca

• There is limited information regarding hyperargininemia inci

  2025-03-01

  

  There is limited information regarding hyperargininemia incidence or prevalence. Reports of incidence vary by an order of magnitude: 0.5 to 5.0 per million [5], [6]. A relatively large U.S. study estimated 1.1 cases per million births [7], but it used an indirect methodology that introduces uncertai

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