• Our experimental results demonstrated http

  2022-01-28

  

  Our experimental results demonstrated marked variability in antioxidant defenses and oxidative damage in Crassostrea gigas between the visceral mass and the gill after the treatments by rifampicin and verapamil through determining the changes of the activity of SOD and POD and MT content. It has bee

• Therefore we investigated the acute

  2022-01-28

  

  Therefore, we investigated the acute and delayed response of 92 human mono- and dizygous twins to an acute shift from low fat to high fat diet with respect to serum levels of VEGF and the expression of SLC2A1 in subcutaneous adipose tissue (AT). By comparing the degree of concordance of basal and di

• The following are the supplementary

  2022-01-28

  

  The following are the supplementary data related to this article. Conflict of interest Acknowledgements This work was supported by JSPS KAKENHI Grant Numbers 24770068 and 15K07152. Introduction Aminoacyl-tRNA synthetases (aaRSs) help maintain the genetic code by recognizing their cognate

• Although our knowledge of how FAs affect GLP producing

  2022-01-27

  

  Although our knowledge of how FAs affect GLP-1-producing L-cells is sparse and incomplete, increased intracellular ceramide [6], ER stress [12], and increased production of ROS [9] are indicated mediators of the lipotoxicity induced by SFA (16:0). However, the role for/interaction between these medi

• In addition recent research shows that HK contributes to the

  2022-01-27

  

  In addition, recent research shows that HK2 contributes to the inhibition of apoptosis through the suppression of the formation of mitochondrial permeability transition pores in association with voltage-dependent anion channel (VDAC) protein [11]. We also found that AKT2 mediates HK2 resistance to a

• br Hedgehog in chronic liver disease The

  2022-01-27

  

  Hedgehog in chronic liver disease The liver responds to different chronic insults with a highly conserved wound healing response during which different cell types must communicate to reconstruct fully functional, healthy liver parenchyma. The inter-cellular dialogue that orchestrates effective li

• br Disclosure statement br Introduction Nitro

  2022-01-27

  

  Disclosure statement Introduction 1-Nitro-2-phenylethane is the first nitro compound isolated from plants [1]. It is a volatile compound found in the essential oil of various species, and its presence provides a pleasant odor that resembles the cinnamon scent [2]. The biogenesis of 1-nitro-2-p

• br Experimental methods br Acknowledgments We

  2022-01-26

  

  Experimental methods Acknowledgments We thank all members of the Hermanson lab, especially Ana Teixeira, Shirin Ilkhanizadeh and Karolina Wallenborg, for assistance and discussions, Peter Löw for anti-synaptotagmin antibody, and Lars Björklund, Ole Isacson, Christer Höög, Claes Wahlestedt and

• br Introduction Glucose homeostasis is primarily regulated b

  2022-01-26

  

  Introduction Glucose homeostasis is primarily regulated by the hormones insulin and glucagon, secreted from the pancreatic islets of Langerhans. Although insulin produced by β Trigonelline is the blood glucose-lowering hormone, glucagon secreted from α cells acts as the major counter-regulatory

• How do myofibroblast sources compare between bone

  2022-01-26

  

  How do myofibroblast sources compare between bone marrow and other organs? Perivascular Neuregulin/Heregulin-1β (NRG-1β/HRG-1β), human recombinant protein with MSC properties significantly contribute to fibrosis in muscle, fat, skin, heart, kidney, lung, and liver (reviewed in Iwayama et al., 2015)

• It is widely acknowledged that CpG methylation

  2022-01-26

  

  It is widely acknowledged that CpG methylation of the promoter regions of some genes plays an important regulatory role in transcriptional regulation and in the establishment and maintenance of cell type-specific gene expression (Li, 2002, Jaenisch and Bird, 2003). This study obtained multiple lines

• Gap junctions mediate electrical coupling between cells by

  2022-01-26

  

  Gap junctions mediate electrical coupling between cells by conducting direct ionic currents and thereby modulate their electrical activity (Hormuzdi et al., 2004). In the nervous system, electrical coupling organizes network activity by amplifying and synchronizing neuronal firing (Galarreta and Hes

• Most of the above mechanisms are

  2022-01-26

  

  Most of the above mechanisms are implicated in attenuation of myocardial I/R injury. However, the role of GalR2 receptor activation in cardioprotection remains unclear because of the lack of receptor subtype selectivity of peptides G2 and G3. It has been shown that Ala5-galanin (2–11) (G4) has a hig

• br G protein coupled receptor GPR also known as a

  2022-01-26

  

  G-protein coupled receptor 40 (GPR40), also known as a free fatty troglitazone receptor, is dominantly expressed in pancreatic β cells and intestine K, L cells., . Besides, GPR40 is also reported to be expressed in brain, but its function is still unknown. It is well documented that GPR40 agonist

• On the contrary the benzhydrol series showed

  2022-01-26

  

  On the contrary, the benzhydrol series showed modest activity with EC of two digit micromole. The bulkiness of the aspirin solubility tail may be the reason for the low activity. Interestingly, introduction of H-bonding groups, such as OMe in and CF in , slightly improved the activity compared to

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