• br Conclusion br Author contributions br Competing interests

  2021-11-09

  

  Conclusion Author contributions Competing interests Acknowledgments Introduction Reproductive performance is a major factor affecting profitability of dairy farms. The use of GnRH and prostaglandin F2α (PGF2α) in a coordinated fashion allows cows to be inseminated as a result of the u

• Overall our results indicated the involvement of GABAAR in

  2021-11-09

  

  Overall, our results indicated the involvement of GABAAR in controlling GnRH/LH release through mechanism which included GABA action on molecular processes leading to GnRH biosynthesis. This is consistent with previous in vivo [14,54] and in vitro [55] studies in ewes suggesting that GABA inhibits G

• 2-Amino-ATP Because sleep and metabolism are intimately link

  2021-11-09

  

  Because sleep and metabolism are intimately linked, the authors next move to study whether Eaat2 also controls metabolic rate. First, we must ask how sleep and metabolism are connected at a functional level. The 2-Amino-ATP allocation hypothesis of sleep posits that organisms temporally partition s

• A number of experimental data declare a

  2021-11-09

  

  A number of experimental data declare a tight interdependence between the pathological changes of glutamate transport in amg express llc and consequent alterations in glutamate transport and activity/expression of glutamate metabolizing enzymes in platelets (Aliprandi et al., 2005, Behari and Shriv

• In a previous paper we demonstrated immunohistochemically th

  2021-11-09

  

  In a previous paper, we demonstrated immunohistochemically the mglur antagonist of GHSR-1a in acrosomes and peripheral region of spermatid heads as well as in acrosomes of the spermatids undergoing spermiation [19]. The present study was undertaken to demonstrate the GHSR-1a expression in rat epidi

• gamma secretase inhibitors Gap junction intercellular commun

  2021-11-09

  

  Gap junction intercellular communication (GJIC) facilitates the exchange of ions, metabolites, Ca2+, inositol phosphates, and/or cyclic nucleotides of up to 1.8 kD in size between gamma secretase inhibitors through contact-dependent mechanisms [3,4]. Oocyte growth and development (as depicted in Fi

• br Materials and methods br Results br Discussion The curren

  2021-11-09

  

  Materials and methods Results Discussion The current study validates a key role for GAL3 receptors in consummatory drive for sucrose, saccharin, and most notably ethanol intake in mice. We show that alcohol preferring mice drink less ethanol compared to wildtype mice when treated with the G

• The second experiment investigated the

  2021-11-09

  

  The second experiment investigated the possible neuronal mechanism underlying the effect of acupuncture. The baseline level of methamphetamine consumption in each group was similar, as in the first experiment (Fig. 2A). Acupuncture at HT7 also significantly inhibited the methamphetamine self-adminis

• To investigate the potential molecular

  2021-11-09

  

  To investigate the potential molecular mechanism of FXR-mediated regulation of liver cancer cell proliferation, gene expression profiles were determined using Agilent arrays in SK-Hep-1-FXR and NC after treatment with the FXR agonist GW4064. The results indicate that mTOR and S6k are involved in div

• All of the abovementioned effects of PUFAs signal their invo

  2021-11-09

  

  All of the abovementioned effects of PUFAs signal their involvement in a cellular phenotype switching phenomenon, which is increasingly recognized as a potential target for future pharmacotherapies of atherosclerosis, especially for individuals who do not respond to the classical lipid-lowering str

• Tianeptine sodium mg In the Medicines for Malaria Venture MM

  2021-11-09

  

  In 2011 the Medicines for Malaria Venture (MMV) distributed the Open-Access Malaria Box to accelerate antimalarial drug discovery (Spangenberg et al., 2013). The Malaria Box consists of 400 structurally diverse compounds, curated from >20,000 hits generated from large-scale screens, that inhibit the

• Overall more males were HCV mono and co infected though

  2021-11-08

  

  Overall, more males were HCV mono- and co-infected, though there was no significant age difference among groups and between men and women (all p>0.05). Almost all patients included in this study were over 40 years, in line with the period in which no HCV screening was performed in Brazilian blood b

• GSTP c C T SNP

  2021-11-08

  

  GSTP1 c.341C > T SNP was genotyped in 90 patients tumor and 180 normal healthy individuals. The profile of GSTP1 c.341C > T Cisatracurium Besylate and genotypes is shown in Table 2. The profile of the genotypes was in agreement with Hardy-Weinberg equilibrium (χ2 = 2.11). Minor allele frequency (341

• Mice lacking S nitrosoglutathione reductase GSNOR a denitros

  2021-11-08

  

  Mice lacking S-nitrosoglutathione reductase (GSNOR), a denitrosylase that regulates S-nitrosylation, have increased levels of S-nitrosoglutathione (GSNO) and exhibit nitrosative stress. GSNO is in equilibrium with protein S-nitrosylation in cells, and GSNOR controls the cellular concentration of pro

• neurokinin receptor In summary we have designed and

  2021-11-08

  

  In summary, we have designed and optimized a new series of 1,4-dioxycyclohexane GPR119 agonists. SAR studies led to the discovery of the preferred molecule that has potent and efficacious GPR119 activity across species. This lead compound exhibited an excellent ADME and safety profile, and demonstr

15959 records 569/1064 page Previous Next First page 上5页 566567568569570 下5页 Last page